Osteoporosis studies

[summerwave]

Dear RRM, Are the osteoporosis studies controlled for [skeletal] fluorosis?

The 2 conditions have diagnostic overlap, and fluoridation of water is (or has been) more widespread in developed countries with public water supplies in densely-populated cities (as opposed to wells in rural/underdeveloped areas).

In re: skeletal fluorosis (from a site that is biased against fluoridation):

http://www.newmediaexplorer.org/sepp/20 ... y_prof.htm

[RRM]

Dear RRM, Are the osteoporosis studies controlled for [skeletal] fluorosis?

I looked into that, previously.
Here it is:
http://www.4.waisays.com/fluoride.htm

[RRM]

From a cohort study (> 22 years of follow-up) in more than 96 000 white postmenopausal women (Nurses Health Study)
and men aged 50 years and older (the US Health Professionals Follow-up Study)Feskanich D et al

"Greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults".
"After controlling for known risk factors and current milk consumption, each additional glass of milk per day during teenage years was associated with a significant 9% higher risk of hip fracture in men"

They contribute this higher risk factor to an increase in height...
Unfortunately, they just compared fracture risk to milk consumption during teenage years (as is thought to be protective),
and not to lifetime milk consumption (or calcium intake).

[Aytundra]

Do bone fractures repair?
or are bone fractures permanent (; unrepairable and...deadly)?

Drug induced bone frailty does it increase bone fractures?
Age induced bone frailty does it increase bone fractures?

Drug induced bone frailty is it reversible if drug stops?
Age induced bone frailty is it reversible if aging process stops?

Drug induced bone pain is it reversible if drug stops?
Age induced bone pain is it reversible if drug stops?

[RRM]

Do bone fractures repair?

Absolutely.
Every single minute of the day, osteblasts make new matrix upon which calcium precipitates, which forms new bone.

or are bone fractures permanent (; unrepairable and...deadly)?

Only if osteoblast replicative capacity is exhausted.

Drug induced bone frailty does it increase bone fractures?
Age induced bone frailty does it increase bone fractures?

Yes, increase bone fracture risk

Drug induced bone frailty is it reversible if drug stops?

Depends on what the drugs did, exactly.
If they only accelerated osteoclast activity, its reversible.

Age induced bone frailty is it reversible if aging process stops?

Can be 'stopped', but not reversed.

Drug induced bone pain is it reversible if drug stops?
Age induced bone pain is it reversible if drug stops?

Depends on the drug

[Aytundra]

The drugs in question are aromatase inhibitors (AI).
The hormone therapy at the end of cancer treatment are AI.
Aromatase inhibitors inhibit proteins that create estrogen.

SIMILAR TO A HIGH-CALCIUM DIET, INADEQUATE ESTROGEN LEVELS STIMULATE OSTEOBLAST ACTIVITY AND INCREASE OSTEOBLAST APOPTOSIS

Logically estrogen production will decrease, hence oestrogen production should decrease.
Unless oestrogen making proteins are shielded from AIs...is that even possible?

More importantly, as osteoporosis is particularly prevalent in postmenopausal women, estrogen deficiency is responsible for increased osteoblastogenesis (54), increases the number of osteoblasts (55) and osteoblast activity (56), accelerating bone formation (49)(54)(57)(58)(59)(60)(61) (and predominantly bone resorption), increasing osteoblast apoptosis rate (62), shortening the lifespan of osteoblasts (63)(64).

Why is osteoporosis prevalent in "postmenopausal" women?

[RRM]

Why is osteoporosis prevalent in "postmenopausal" women?

Because estrogen is protective aginst excessive calcium intakes.

[Aytundra]

Original research article:
http://www.bmj.com/content/349/bmj.g6015
Milk intake and risk of mortality and fractures in women and men: cohort studies

Web article summary:

The Swedish Mammography Cohort: a group of 61,433 women, aged 39-74 in 1987-1990
The Cohort of Swedish Men: a group of 45,339 men, aged 45-79 in 1997.
...

The Swedish Mammography Cohort
Over the 20 years that the women were tracked:

15,541 died
17,252 had a fracture; of these, 4,259 had a hip fracture.
No reduced risk of fracture with higher milk consumption was observed. Women who drank more than three glasses of milk a day (average 680 ml) had a higher risk of death than women who drank less than one glass of milk a day (average 60 ml).

...

The Cohort of Swedish Men
Over the duration of the 11 years that the men were tracked:

10,112 died
5,066 had a fracture; of these, 1,116 had a hip fracture.
Although less pronounced than in the female group, men also had a higher risk of death with higher milk consumption.

[RRM]

Yes, bone porosity is heavily linked to uncurable hip fractures, which is a life threathening condition in elderly.