Aytundra wrote: Yes, more thieves in a city might lower crime rates temporarily, as most criminals in this imaginary city are too busy plotting a heist.
Temporarily, in that short moment of time everything is perfect, fructose is where it should be being turned into glucose or glycogen.
As the glucose and glycogen stores build up and more and more fructose is added, eventually the glycogen stores will fill-up, glycogen to triglycerides form, and excess fructose awaits processing.Without the capacity to meet excess fructose, excess fructose wanders and then we might have a problem.
Let's pretend fructose systems' maximum capacity = 100 fructose molecules:
- If we have liver and sucrase system at full capacity [100],
and we put in some fructose (5 fructose),
then there will be some fructose (like 3 fructose, while the other 2 fructose trickle into the system as the system outputs 1 glycogen) wandering endogenously, a probability that endogenous AGEs might form from these (three) fructose.
- If we have liver and sucrase system at vacant capacity [0],
and we put in a lot of fructose (102 fructose),
then there will be a lower probability (relative to other liver, sucrase system scenarios) that endogenous AGEs might form.
- If we have liver and sucrase system at half capacity [50], and we put in a lot of fructose (75 fructose),
then there will be some left over fructose (25 fructose),
then there will be some probability that endogenous AGEs might form from the (20) extra fructose wandering.
- If we have liver and sucrase system at full capacity again [100],
and we put in a lot of fructose (60 fructose),
there will be a lot of fructose not processed yet (~50), and these might wander and form endogenous AGEs if the climate is right.
- If liver capacity are full, and the liver stores glycogen as fats, the fats now has a chance to become ALEs if given the right circumstances.
-- Hence the heist, not only potential of AGEs from fructose, but also potential for ALEs from fructose after the liver processing.
-- But we don't have to be scared, just use up glycogen and use up liver fat accordingly. They may plot but we may empty.
--- But what if the systems are damaged?
--- What if we don't empty at the right times accordingly?
AGEs ALEs bad?
- If we have a lot of fructose in the body not converted into glucose, glycogen or stored as glycogen depots, then they are free to wander around.
Like an elevator, if we have lots of people waiting for an elevator these people wander the hallway.
- Wandering reducing sugars are not bad, and things they do are not necessarily bad.
- As you have pointed out not all AGEs or ALEs formed are bad, they don't necessarily correlate to bad health, like your opinion on CML and veggie/fruit eaters.
But it matters who is waiting at the elevators.
If I have adults (glucose) versus toddlers (fructose) at the elevator doors, toddlers will be more prone to activity, and some activities make a mess, some a bad mess (bad AGEs).
I don't have to worry much for sucrose (adults minding a toddler), in a sucrase pathway.
Only when sucrase capacity is full, then do I have to worry about sucrose and perhaps with attention to the fructose that sucrose contains.
- Glucose is readily used in the body, but fructose must be converted before it can be used.
- Glucose is a reducing sugar, it may form endogenous AGEs if given the right circumstances.
- Fructose is a reducing sugar, it may form endogenous AGEs if given the right circumstances.
- But because glucose has a higher probability of being used by the body,
since, a glucose molecule floating freely might meet a muscle cell that needs some energy,
while, a fructose molecule floating freely might meet a muscle cell and cannot be used for energy immediately,
then a fructose is a more inert reducing sugar to have floating around, ("inert" relative to the ease of usage for energy).
